White Sox vs. Guardians Prediction, Betting Tips & Picks 4/21/2022

The Chicago White Sox (6-5), led by Luis Robert on a two-game home run streak, are -141 favorites on the moneyline to defeat Jose Ramirez (homers in two straight contests) and the Cleveland Guardians (6-4). First pitch is at 1:10 PM ET on Thursday, live from Progressive Field. Chicago’s Dylan Cease gets the start, and he’ll go against Cleveland’s Zach Plesac.

White Sox vs. Guardians Spread and Betting Line

Computer Predictions for White Sox vs. Guardians

Our computer pick: Cleveland Guardians (+120) and Over (8)

White Sox vs. Guardians Game Info

• Chicago White Sox probable starting pitcher: Dylan Cease
• Cleveland Guardians probable starting pitcher: Zach Plesac
• Game Day: Thursday, April 21, 2022
• Game Time: 1:10 PM ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field

Chicago White Sox vs Cleveland Guardians Pitching Matchup

White Sox Starter Dylan Cease

• Cease (2-0) makes the start for the White Sox, his third of the season.
• The right-hander last pitched on Friday against the Tampa Bay Rays, when he tossed 5 2/3 innings, allowing one earned run while giving up three hits.
• He has a 1.69 ERA and 13.5 strikeouts per nine innings while opponents are batting .139 against him over his two games this season.
• The opposing Guardians offense has the best slugging percentage (.448) and is 14th in MLB play with 10 home runs. It has a collective .276 batting average, and is 10th in MLB with 98 total hits and third in MLB action scoring 61 runs.

Guardians Starter Zach Plesac

• Plesac heads to the mound for the Guardians to make his third start of the season, seeking his first win.
• The right-hander last pitched on Friday against the San Francisco Giants, throwing 5 1/3 innings and giving up two earned runs.
• He has pitched to a 1.64 ERA this season with 5.7 strikeouts per nine innings compared to 0.8 walks per nine across two games.
• In two starts, Plesac has pitched through or past the fifth inning two times. He has a season average of 5.2 frames per outing.
• The White Sox rank 22nd in MLB with a .209 batting average this season. They have a team slugging percentage that ranks 22nd in the league (.345) and 10 home runs.
• Among qualified pitchers this season, the 27-year-old’s 1.64 ERA ranks 14th, 1.000 WHIP ranks 16th, and 5.7 K/9 ranks 53rd.

White Sox Betting Picks & Insights

• This season, the White Sox have been favored eight times and won six of those games.
• Chicago has played as a favorite of -141 or more once this season and won that game.
• The moneyline for this contest implies a 58.5% chance of a victory for the White Sox.
• So far this season, Chicago and its opponents have hit the over in five of their 12 games with a total.
• The White Sox are 5-7-0 against the spread in their 12 chances this season.

Guardians Betting Picks & Insights

• The Guardians have won in three of the five contests they have been named as odds-on underdogs in this year.
• Cleveland has played as an underdog of +120 or more just one time this year and came away with a loss in that game.
• Oddsmakers have implied with the moneyline set for this matchup that the Guardians have a 45.5% chance of pulling out a win.
• Cleveland and their opponents have hit the over in five of their 11 games with a total set by oddsmakers this season.
• The Guardians have posted a record of 6-5-0 against the spread this season.

White Sox Leaders & Batting Stats

• Tim Anderson has four doubles, a home run and a walk while batting .375.
• Robert’s two home runs lead his team.
• Robert ranks 29th in homers in MLB, and 153rd in RBI.
• Robert heads into this game looking for his sixth game in a row with a hit. In his last five games he is batting .000 with .
• Andrew Vaughn has hit a team-high two home runs.
• Vaughn has at least one base hit in four games in a row. During his last five outings he is batting .188 with a double.
• Jose Abreu is batting .216 to pace his team.

Guardians Leaders & Batting Stats

• Ramirez leads the Guardians with four home runs and 20 runs batted in, while recording a team-high batting average of .447.
• Among all hitters in MLB, Ramirez’s home run total ranks fifth and his RBI tally is first.
• Ramirez has collected a hit in six games in a row. In his last 10 games he is hitting .447 with five doubles, a triple, four home runs, four walks and 20 RBI.
• Myles Straw is hitting .317 with two doubles, a triple and eight walks.
• Straw ranks 190th among all hitters in the big leagues in home runs, and 206th in RBI.
• Steven Kwan is hitting .387 with three doubles, a triple and eight walks.
• Oscar Mercado is hitting .222 with two doubles, a triple and three home runs.

Betting Tips for White Sox vs. Guardians

We have the Guardians on the moneyline at +120 on the moneyline as our best bet in this contest after digging through all of the key trends and stats for this matchup. Our computer prediction sees the scoring going over the total of 8 runs.