Los Angeles Rams vs. San Francisco 49ers NFL Playoffs Betting Tips and Best Bets

by | Jan 25, 2022

The bookmakers think this year’s NFC Championship Round game between the Los Angeles Rams and San Francisco 49ers will be a relatively close one, with the Rams favored by 3.5 points. SoFi Stadium in Inglewood, California will host the matchup on January 30, 2022, starting at 6:30 PM ET. The over/under for the outing is 46.5 points. Find more below on the Rams vs. 49ers betting line, injury report, head-to-head stats, best bets and more.

Rams vs. 49ers Betting Line and Game Info

Rams vs 49ers Betting Information
Favorite Spread Favorite spread odds Underdog spread odds Total Over total odds Under total odds
Rams -3.5 -102 -118 46.5 -110 -110
  • Game Day: Sunday, January 30, 2022
  • Game Time: 6:30 PM ET
  • TV Channel: FOX
  • Location: Inglewood, California
  • Stadium: SoFi Stadium

Rams vs. 49ers Best Bets

Prediction for Rams vs 49ers
Spread Pick Total Pick Predicted Score
Rams (-3.5) Over (46.5) Rams 26, 49ers 21

Rams vs. 49ers Betting Tips

  • Los Angeles’ record against the spread is 8-9-0.
  • The Rams have an ATS record of 6-8 as 3.5-point favorites or greater.
  • Los Angeles has seen nine of its 17 games go over the point total.
  • The Rams have put an average of 27.1 points per game on the board this season, 5.6 more than the 21.5 the 49ers have surrendered.
  • Los Angeles is 10-2 overall when scoring more than 21.5 points this year.
  • The Rams have a 62.1-yard advantage in average yards gained versus yards allowed compared to the 49ers (372.1 to 310.0). The Rams average 6.2 yards per play, while the 49ers give up 5.5.
  • When the Los Angeles offense puts together a game with more than San Francisco’s 2021 average in yards allowed (310.0 per game), it is 12-3.

Los Angeles Rams Leaders

  • Matthew Stafford has thrown for 4,886 yards, completing 67.2% of his passes and tossing 41 touchdowns and 17 interceptions this season. He’s also run for 43 yards (2.5 ypg) on 32 carries.
  • Sony Michel has 845 rushing yards on 208 carries with four touchdowns.
  • Cooper Kupp’s leads his squad with 1,947 yards as a receiver. He’s racked up that yardage on 145 receptions (out of 191 targets) and scored 16 touchdowns.
  • Aaron Donald has 12.5 sacks to pace the team, and also has 19.0 TFL and 84 tackles.
  • Troy Reeder is the team’s tackle leader this year. He’s totaled 90 tackles, 6.0 TFL, two sacks, and two interceptions.
  • Jalen Ramsey has a team-high four interceptions to go along with 76 tackles, 9.0 TFL, and 16 passes defended.

Los Angeles Rams Season Stats

Stat Average (Total) Rank
Pass yards 287.8 (4893) 5
Rush yards 99.0 (1683) 25
Points scored 27.1 (460) 7
Pass yards against 263.3 (4476) 24
Rush yards against 103.2 (1754) 6
Points allowed 21.9 (372) 15

49ers vs. Rams Betting Tips

  • San Francisco is 9-8-0 against the spread this year.
  • The 49ers have an ATS record of 5-1 as 3.5-point underdogs or greater.
  • There have been eight San Francisco games (out of 17) that hit the over this season.
  • The 49ers, on average, are scoring 3.2 more points per game this year (25.1) than the Rams are allowing (21.9).
  • When it exceeds what Los Angeles gives up this season (21.9 points per game), San Francisco is 9-2.
  • The 49ers’ offense holds a 30.8-yard advantage in yards gained per game versus yards allowed by the Rams’ defense this season (375.7 to 344.9). The 49ers average 6.3 yards per play, while the Rams give up 5.6.
  • San Francisco’s record this season when it racks up more than Los Angeles’ season average in yards allowed (344.9 per game): 7-3.

San Francisco 49ers Leaders

  • Jimmy Garoppolo has racked up 3,810 yards (224.1 ypg) while completing 68.3% of his passes and recording 20 touchdown passes with 12 interceptions this season.
  • Elijah Mitchell has run for 963 yards on 207 carries so far this year while scoring five times on the ground.
  • Nick Bosa has racked up 15.5 sacks to lead the team, while also recording 21.0 TFL and 52 tackles.
  • Fred Warner is the team’s top-tackler this year. He’s totaled 137 tackles, 7.0 TFL, and 0.5 sacks.
  • Jimmie Ward leads the team with two interceptions, while also putting up 75 tackles, 1.0 TFL, and six passes defended.

San Francisco 49ers Season Stats

Stat Average (Total) Rank
Pass yards 261.0 (4437) 12
Rush yards 127.4 (2166) 7
Points scored 25.1 (427) 12
Pass yards against 227.9 (3874) 7
Rush yards against 103.5 (1760) 7
Points allowed 21.5 (365) 11

Rams and 49ers Injury Report

Player Pos. Injury Status
Player Pos. Injury Status


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